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The syndrome includes many of the severe reactions described above, and is potentially life-threatening and fatal.

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It has been reported that symptoms may develop in approximately 1 week from initiating allopurinol therapy, but longer latency periods have also been reported. Acute attacks of gout. The most frequent event observed was acute attacks of gout following the initiation of therapy. Body As a Whole: Thrombocytopenia, eosinophilia, leukocytosis, leukopenia.

Peripheral neuropathy, neuritis, paresthesia, somnolence. Pericarditis, peripheral vascular disease, thrombophlebitis, bradycardia, vasodilation.

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In patients with pre-existing liver disease, periodic liver function tests are recommended during the early stages of therapy. Due to the occasional occurrence of drowsiness, patients should be alerted to the need for due precaution when engaging in activities where alertness is mandatory.

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